Abrocitinib intermediates

 

CIBINQO (abrocitinib)

CAS RN: 1622902-68-4

Chemical Name:

N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide

Company: Pfizer

 

Abrocitinib is an orally available, small molecule inhibitor of Janus kinase 1 (JAK1) that is used to treat moderate-to-severe atopic dermatitis. Abrocitinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury.

 

One synthetic route

Abrocitinib intermediates

benzyl (3-oxocyclobutyl)carbamate 130369-36-7

3-oxocyclobutanecarboxylic acid 23761-23-1

isopropyl 3-oxocyclobutanecarboxylate 130111-95-4

4-chloro-7H-pyrrolo[2,3-d]pyrimidine 3680-69-1

1-(propylsulfonyl)-1H-1,2,4-triazole 2407868-85-1