Sotorasib intermediates

 

Lumykras (sotorasib)

CAS RN: 2296729-00-3

Chemical Name:

6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one

Company: AMGEN INC

Patent: US20180334454A1, Kras g12c inhibitors and methods of using the same

 

Sotorasib, also known as AMG-510 is an inhibitor of the RAS GTPase family indicated for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), who have received at least one prior systemic therapy.

 

One synthetic route

Sotorasib intermediates:

2,6-dichloro-5-fluoronicotinic acid, CAS 82671-06-5

2,6-dichloro-5-fluoronicotinamide, CAS 113237-20-0

2-isopropyl-4-methylpyridin-3-amine, CAS 1698293-93-4

tert-butyl 3-methylpiperazine-1-carboxylate, CAS 120737-59-9

(S)-tert-butyl 3-methylpiperazine-1-carboxylate, CAS 147081-29-6

potassium trifluoro(2-fluoro-6-hydroxyphenyl)borate, CAS 2252415-10-2